About Entrechem  >  Key Personnel

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Our talented key personnel includes both experienced and young professionals
with diverse and complementary technical backgrounds.

Francisco Morís, Ph.D.
Managing Director

Francisco Morís received his Ph.D. in 1994 from the University of Oviedo (Spain) under the supervision of Prof. Vicente Gotor. Following his Ph.D. studies, he worked two years in the labs of Prof. Chi-Huey Wong at The Scripps Research Institute in La Jolla (USA).

In 1997 he joined the biocatalysis firm ThermoGen, Inc. (Chicago, IL), where he worked as Associate Director of Biocatalysis focusing on high-throughput assay development and biocatalytic process development. ThermoGen merged in May 2000 with MediChem Research, in turn acquired by deCode Genetics on March, 2002. From September 2002 until Dec 2004 he worked at Bristol-Myers Squibb (Syracuse, NY), in the biotransformations group, developing a large scale process for saxagliptin.

In 2005 he came back to Spain to set up EntreChem, a start up company focused on drug discovery and development of new drugs based on combinatorial biosynthesis and biocatalysis. Francisco is co-author of over 25 scientific international publications, co-inventor in over 12 patents and has raised 3MEUR to date from local Business Angels, Family Offices and Public Agencies.

Jesús Cortés, Ph.D.
Director, Molecular Biology

A native of Mexico, Dr. Cortés holds a Ph.D. in Microbiology by the University of León, Spain, moving then to the UK, where he spent 23 years in various positions. During his stay in Cambridge University as Senior Research Associate in the group of Prof. Peter Leadlay, Jesús identified and characterised for the first time modular polyketide synthase encoding genes (published in Nature) and established methodologies for efficient genetic manipulation of this type of enzymes (published in Science) allowing the production of novel hybrid polyketide compounds. The work carried out in this project was the basis of Biotica, a Cambridge University spin-off Company.

Later, he moved to GlaxoSmithKline in Stevenage, as Senior Molecular Biologist in the Natural Products and Biotransformations Unit, where he supervised a research group to use molecular biology tools to manipulate actinomycetes of the Company’s collection as well as established genetic methods for production of new macrolide antibiotics and developed systems to carry out protocols of molecular evolution of enzymes involved in biotransformation processes. In 2003, he moved to Novacta Biosystems Ltd, first as Group Leader and more recently as Director of Molecular Biology in the therapeutics arm of the Company, where he was responsible, among other projects, for the discovery and preclinical development of an antibiotic active against Gram-negative organisms.

Luz Elena Núñez, Ph.D.
Project Manager, Molecular Biology

Luz Elena Núñez graduated in Biology in 1997 at the University of Oviedo. She is a molecular biologist specialized in genetic engineering of biosynthetic pathways of secondary metabolites in Streptomyces. Luz Elena did her Ph.D. on cloning and engineering of the biosynthetic pathway of the antibiotic thienamycin in Prof José Salas group at the University of Oviedo.

Luz Elena carried out postdoctoral studies with Prof Juan F. Martín at INBIOTEC (León, Spain) before joining Entrechem in 2006, where she is currently Project Manager at the Molecular Biology Department. She is involved in the manipulation of genes responsible for the biosynthesis of novel drug candidates in order to improve properties and production levels.

Javier González-Sabín, Ph.D.
Project Manager, Biocatalysis

Javier González-Sabín (born 1979) graduated in Chemistry in 2001 at the University of Oviedo and carried out his Ph.D. under the supervision of Prof. Vicente Gotor and Dr. F. Rebolledo. His Ph.D. research involved the chemoenzymatic preparation of biologically active compounds and the study of the mechanism for the enzymatic aminolysis reaction. During his doctoral studies, he spent a stay at the University Jaume I (Castellón) with Prof. Santiago V. Luis, working on supramolecular chemistry and asymmetric catalysis.

After finishing his doctorate in 2005, he moved to EntreChem S.L, where he is currently working as project manager at the Biocatalysis Department. For the past 7 years he has been involved in many projects regarding bioprocess development for pharmaceutical intermediates and fine chemicals as well as chemoenzymatic modification of complex natural products. He is co-author of 28 scientific international publications and co-inventor of 5 patents.

Paula Costales, Ph.D.
Senior Scientist, Cell Biology

Paula Costales graduated in Biology in 2002 at the University of Oviedo. Paula obtained her Ph.D. under the supervision of Prof. Badimon and Dr. Llorente at the Cardiovascular Research Center (CSIC-ICCC) in 2009.

Her Ph.D. work was mainly focused on the transcriptional mechanism involved in the LRP-1 (LDL receptor related protein -1) upregulation by cholesterol and on the role of different transcription factors. She worked as a postdoc at the Cardiovascular Research Center until she joined EntreChem S.L. in May 2010.