Colorectal cancer (CRC) shows alterations on the activation status of receptor tyrosine kinases (RTKs) and intracellular cytoplasmic kinases, some of which correlate between primary tumors and liver metastases. EC-70124, a... read more →
Triple Negative Breast Cancer (TNBC) at the molecular level shows alterations on receptor tyrosine kinases (RTKs), downstream signaling pathways involved in the regulation of proliferation and survival, and DNA repair... read more →
ESE1/ELF3 and NF-kB are co-activated in selected prostate tumors and associated with adverse prognosis in prostate tumors, according to researchers at the IOR (Switzerland). EC-70124, a kinase inhibitor being developed... read more →
The fusion protein EWS-FLI1 ins a constitutively activated transcription factor responsible for the oncogenic phenotype of Ewing sarcoma. Mithramycin was identified last year out of 50.000 compounds as a potent... read more →
The PI3K/Akt/PTEN molecular pathway is frequently mutated in this type of tumor, where activation of the Akt kinase is a poor prognosis factor, according to researchers at CIEMAT. EC-70124, a... read more →
Glioblastoma initiating cells activate NFkB cell signaling pahtway to avoid terminal differentiation, according to researchers in Hospital Valdecilla. EC-70124, an inhibitor of NfkB pathway under development at EntreChem SL, has... read more →