Modification of only one out of several identical functional groups in a molecule is a fundamental challenge to organic chemists, for example the regioselective modification of polyhydroxy compounds.

Enzymatic catalysis has become a common tool routinely incorporated into many synthetic sequences. In our case, a further step consists in expanding the application of enzymes to the modification of complex molecular scaffolds common to many pharmaceutical leads isolated from nature. EntreChem applies regioselective enzymatic modifications of natural products to  discover new natural product analogs with improved activity, stability and pharmacokinetic properties.

We also explore the implementation of cascade reactions including organo-, bio- and metal-catalyzed steps. Such strategy offers advantages over conventional chemical or catalysis step-wise reactions, and brings closer the possibility of emulating nature for the synthesis of complex natural products.

Enantiomerically Pure Chiral Building Blocks

Chiral building blocks are essential to create sophisticated MedChem libraries, or as starting materials for Process Development of chiral APIs. Orthogonal protection strategies enable attachment and cleavage of different protecting groups to multifunctional molecules, and it is a valuable tool for the synthesis of a wide range of hydroxy- and amino compounds.

The adequate arrangement of protecting groups attached to the diamines allow us to prepare valuable orthogonally protected cycloalkane-1,2-diamines and 1,2-amino-alcohols in enantiomerically pure form. The protecting groups are easily removable, to differentiate both functional groups for the modular synthesis of a wide and novel range of derivatives.

Please, contact us to obtain an updated price list, availability and purchase terms.
Also, contact us for the custom synthesis of related products not found on the list.